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The organic content was analyzed using data-dependent auto LC-MS (maXis, Bruker Daltonics) coupled to an UHPLC ACQUITY (Waters) using reverse phase chromatography (CORTECS UPLC C18 column, 150 mm 2.1 mm ID 1.6 m, Waters Corporation) in both positive and negative electrospray modes

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In line with this, a study using postmortem brain tissues from PD patients and controls, as well as monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), found over-expression of ICAM-1 in the substantia nigra of patients with PD and in the MPTP monkeys [156]

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