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We found that the ebselen could significantly promote SGN survival, decrease SGN apoptosis, and reduce intracellular ROS levels after peroxynitrite exposure in vitro , while the deficiency of GPX1 led to opposite patterns of the above effects

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In particular, the inhibition of CRHR2 in pancreatic SST-secreting cells by Ast2B promoted insulin release from neonatal islets in the resting state, and Ast2B administration caused an increase in the blood insulin level (Figs

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