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The detailed elucidation of these multiple ROS sourcesmitochondria, NADPH oxidase, xanthine oxidase, and CYP450 enzymesreveals that oxidative stress in PCOS is a complex, multi-factorial burden, not attributable to a single pathway

A broader review found it might brighten skin in sun-exposed areas but labeled the overall evidence as "inconclusive" due to mixed study quality (PubMed Systematic Review)

Korean J Ophthalmol: KJO (2022) 36(1):3643

Some protocols use an extended break matching the cycle length (8 weeks on, 8 weeks off)

Le Page A, Dupuis G, Larbi A, Witkowski JM, Fulop T