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Frank deficiency, other procedures or non-bariatric weight loss: sublingual or oral methylcobalamin 2000 mcg daily

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The 2018 paper in Biochemical Pharmacology gave obese mice a membrane-permeable NNMT inhibitor and reported it significantly reduced body weight and white adipose mass, decreased adipocyte size, with the mice eating the same amount as before, and the authors noting the inhibitors did not impact total food intake nor produce any observable adverse effects [1]

Mahadev, K

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