The BMC Chemistry Journal conducted studies on two commercially available nicotine pouch products and compared them with regular smokeless tobacco and pharmaceutical grade nicotine replacement therapy (NRT) products
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[DOI] [PubMed] [Google Scholar] 28.Haissaguerre M, Shah AJ, Cochet H, Hocini M, Dubois R, Efimov I, Vigmond E, Bernus O, and Trayanova N
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Prescription VIP therapy is a more targeted intervention used later in certain CIRS protocols, while nicotine is better understood as a possible temporary adjunct rather than a substitute