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Unfortunately, oxidative stress may be what causes you to develop migraine disease because the buildup of ROS tips the balance of inflammatory and anti-inflammatory processes in favor of inflammation, triggering inflammatory cascades that lead to migraine attacks

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It inhibits NF-B and other inflammatory cytokine cascades, downregulates COX-2 and LOX enzymes, enhances glutathione levels, improves insulin signaling, promotes detoxification by supporting phase II liver enzymes, and regulates immune cell activation

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It may vary depending on the individuals circadian rhythm, but according to the results of a meta-analysis, administration at 18:00 or 20:00 h may be the most effective [84]