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These effects are often dose-related and can usually be improved by adjusting the dose or injection schedule

p- value 0.0001], though studies have a high degree of heterogeneity ( I 2 = 72%) (Fig

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Combination with immunotherapy (e.g., anti-PD-1) promotes immunogenic ferroptosis by increasing the infiltration of CD8 + T-cells, while combination with chemotherapy (e.g., 5-fluorouracil) increases chemosensitization in CRC cells (35, 36)

Udovicic M, Sever M, Kavur L et al (2021) Stable gastric pentadecapeptide BPC 157 therapy for monocrotaline-induced pulmonary hypertension in rats leads to prevention and reversal