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Developmental pharmacokinetics

Anal Biochem 1999

Published 2018 Jul 7

There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH

Additionally, laboratories may evaluate multiple compounds within the same category to better understand formulation consistency, preparation considerations, and analytical performance

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