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Chronic studies in cynomolgus monkeys revealed no adverse events at a dose of 20 mg/kg per day [88], and high-dose supplementation in rhesus monkeys caused no ocular toxicity [89]

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265 Likewise, CXXC5-type zinc finger protein 5 (CXXC5) negatively regulates the Wnt/catenin pathway by directly interacting with DVL

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In fact, in one 6 month study, participants were given either 250 mg per day or 1,000 mg per day of reduced glutathione