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The synthesis constitutes a formal total synthesis, since the research groups only prepared the known intermediate cobyric acid, whose chemical conversion to vitamin B 12 was previously reported

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In addition, combined treatment with GPNA and a monoclonal antibody (cetuximab) targeting EGFR effectively suppressed the growth of gastric cancer cells in vitro and in vivo 86

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Only for the growth-hormone-deficiency pattern (poor sleep + low recovery)