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Reduced concentrations of N-acetyl aspartate and total creatine in the basal ganglia are markers of neuronal loss and impaired energy metabolism, which correlate with cognitive dysfunction and motor deficits ( Behavioral assessments aligned closely with these imaging findings, offering a clinical perspective on the neurological damage caused by METH abuse
Fused heterocyclic ring systems ( 3 5 ) may have substantially different properties to the parent compound, such as lipophilicity, polar surface area and hydrogen-bonding groups, which can lead to loss of biological activity 23
Yoon DH, Kwon OY, et al
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