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318 Hypoglycemic agents for patients with T2D and CKD CKD, diagnosed by a persistent increase in urinary albumin excretion (albuminuria), a low estimated glomerular filtration rate (eGFR), or other manifestations of kidney damage, may be a consequence of DN and nondiabetic nephropathy coincident with T2D
Hycobal Inj
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No controlled human trials confirm the frequency or severity of the symptoms
observed that exogenous glutamate inhibits cystine uptake through the cystine/glutamate antiporter system, depleting GSH and inducing an increase in ROS levels and intracellular Ca2+ influx, causing a form of programmed cell death in neuronal cells distinct from apoptosis (22)
