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Dermatol Ther 2022, 12 (11), 24152452

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When the mitochondrial matrix experiences high osmotic pressure, the MPTP channel opens, leading to apoptosis

In some embodiments, the solution formulation or composition also has an immediate or rapid release component for delivery of the therapeutic agent to the desired target site

After 72 h, the overlay was removed, cells were fixed in 6% formaldehyde and plaques were visualized by crystal violet staining