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The influence of the environment via epigenetic mechanisms, i.e., heritable modifications of gene expression that do not alter the DNA sequence, is suspected to have a central role in the etiopathology of endometriosis [7, 8]

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The result is a range of digestive and systemic symptoms that mimic other gastrointestinal disorders such as IBS, celiac disease, or food intolerances

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To quench the metabolism, 500 l of precooled -48 C 100% methanol (Sigma, Germany) was added to the cells, which were then incubated for 30 minutes at -80 C

A less commonly discussed effect: choline can produce a temporary fishy body odor in a small number of people due to the way it is metabolized