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In addition, IONIS-DGAT2 Rx , an ASO targeting diacylglycerol acyltransferase 2 (DGAT2, an enzyme that catalyzes the final step in TG synthesis in the liver), improved liver steatosis in patients with NASH in phase 2 clinical trial (NCT03334214)

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In the brain, both substances can influence mood

Day 1: Cochlea were transferred to antibiotic free media supplemented with 0%, 2%, or 10% FBS, 0.5% DMSO (unless otherwise noted), and treated with cisplatin (range of concentrations) for 48-72 hours

This, in turn, fights depletion of muscle glycogen stores

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