Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans
Similarly, the telomerase inhibitor imetelstat triggers apoptosis in patient-derived xenograft models while concurrently inducing ferroptosis through polyunsaturated fatty acid (PUFA)-phospholipid accumulation, suggesting shared upstream stress sensors [148]
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In prenatally hypoxic rats, being treated with nMitoQ could suppress the rise in ROS and attenuate the heart diastolic dysfunction, especially in female progeny 514 Furthermore, improved cardiac tolerance after adulthood could be seen in the offspring of these prenatal hypoxic pregnant rats administrated with nMitoQ
