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Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown

This mechanism may provide pain relief without the tolerance and dependence issues associated with direct opioid receptor agonists

The rats were obtained from Shahid Beheshti Medical University, weighed between 220 20 g, and were 8 weeks old

Aluminum hydroxide (Alum) is used as an adjuvant to enhance immunogenicity, while excipients such as phosphate buffers and sodium chloride help maintain isotonicity

A rodent study by Wang et al

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