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Hydroxocobalamin 1mg is the standard UK formulation, typically administered every two to three months for maintenance therapy Self-administration requires GP prescription, competency training from practice nurses, and demonstration of proper injection technique Common injection sites include the thigh (vastus lateralis) for both intramuscular and subcutaneous administration with site rotation essential Serious side effects are rare but anaphylaxis requires immediate 999 call

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Cyanocobalamin is the most common and cost-effective form in over-the-counter supplements, whilst hydroxocobalamin is preferred for injections in the UK as it has a longer duration of action

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