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Steeghs, K., Oerlemans, F

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Nutr Neurosci 24(4):363370

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A cardiac-centred approach to HFpEF diagnosis using NPs is a good starting point, and is actually promoted by the Heart Failure Association through the Peptide for Life initiative.165 However, a holistic approach including biomarkers that provide information on non-cardiac components of the HFpEF syndrome may enrich our understanding of the disease and may be useful in classifying HFpEF phenotypes/endotypes that may guide patient selection in HFpEF trials ( Figure 1 ).166 Because of the risk of bias in current HFpEF biomarker studies, methodologically well-designed studies with a uniform reference diagnosis are urgently needed to determine the incremental value of circulating biomarkers for the diagnosis of HFpEF.167

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The dephosphorylation of -catenin contributes to -catenin accumulation in the cytoplasm, playing a positive role in Wnt signal transduction

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Epitalon in a Longevity Protocol: What Clinicians Consider Clinicians who integrate epitalon into longevity protocols typically position it as part of a stacked approach, not a standalone intervention

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Science 140 , 184186 (1963)

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