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According to the AIE mechanism, the fluorescence of these dyes can be turned on/off if the analyte can alter the aggregation behavior (solubility) or the intramolecular motions of the fluorescent species 55,56

The panel agreed that initial treatment should be parenteral for severe cases, while high-dose oral B12 can be considered for maintenance

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The glutathione content of the hepatocytes was determined by Ellman`s method using spectrophotometer

Also oral administration, although with conflicting results, resulted in increased serum GSH levels with reduced oxidative stress and beneficial effects in several diseases (27, 28)