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10.1007/BF01119794 Biosci

doi: 10.1002/MNFR.201100251 274 VissersYMIwanMAdel-PatientKStahl SkovPRigbyNMJohnsonPEet al

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Conversely, when blocking was omitted, intense fluorescence was obtained in both the cytoplasmic and nuclear compartments ( Figure 2C )

CK7: Cytokeratin 7 CK19: Cytokeratin 19 IL-33/ST2: Interleukin 33/Suppression of Tumorigenicity 2 IM: Infiltrating monocytes/inflammatory monocytes FGF21-MSCs: Fibroblast growth factor 21-mesenchymal stem cells LGG: Lactobacillus rhamnosus GG CGMCC 7049: China General Microbiological Culture Collection Center 7049 MIP-1: Macrophage Inflammatory Protein 1 MCP-1: Monocyte Chemoattractant Protein 1 PNPLA3: Patatin-Like Phospholipase Domain-Containing Protein 3 ADH: Alcohol Dehydrogenase ALDH: Aldehyde Dehydrogenase MTP: Microsomal Triglyceride Transfer Protein GST: Glutathione S-Transferase APOE: Apolipoprotein E HFE: Hemochromatosis Protein PMPs: Platelet Microparticles NETs: Neutrophil Extracellular Traps GPIb: Glycoprotein Ib Alpha ECs: Endothelial Cells HMs: Hepatic Macrophages mtDNA: Mitochondrial DNA TLR9: Toll-Like Receptor 9 Nr1d2: Nuclear Receptor Subfamily 1 Group D Member 2PPar, Peroxisome Proliferator-Activated Receptor Alpha TLR-4: Toll-Like Receptor 4 16S rRNA: 16S ribosomal RNA GVB: Gut Vascular Barrier FMD: Fasting-Mimicking Diet GS: Glycogen Synthesis G6P: Glucose-6-Phosphate PPP: Pentose Phosphate Pathway NADPH: Nicotinamide Adenine Dinucleotide Phosphate R5P: Ribose-5-Phosphate NKT: Natural Killer T cell NO: Nitric oxide MDM: Monocyte-derived macrophages LCM: Liver capsule macrophages CXCL: C-X-C Motif Chemokine Ligand HCC: Hepatocellular Carcinoma Tregs: Regulatory T Cells LCN2: Neutrophil-derived lipocalin-2 CXCR2: CXC chemokine receptor 2 NKG2D: Natural Killer Group 2 Member D CD107a: Degranulation Marker IFN-g: Interferon-g NKG2A: Natural Killer Group 2 Member A cDC: Conventional Dendritic Cells pre-DCs: Pre-Dendritic Cells HDC: Hepatic Dendritic Cells MAIT: Mucosal-Associated Invariant T Cells WT: Wild-Type HFD: High-Fat Diet CD: Control Diet SAT: Subcutaneous Adipose Tissue VAT: Visceral Adipose Tissue T-bet: T-box transcription factor IL-13Ra2: Interleukin 13 Receptor Alpha 2 ECM: Extracellular Matrix PPAR-: Peroxisome Proliferator-Activated Receptor Gamma SREBP-1c: Sterol Regulatory Element-Binding Protein 1c FAS: Fatty Acid Synthase VL 6: Very-Long-Chain Fatty Acid Protein 6 PI3K/Akt: Phosphoinositide 3-Kinase/ Protein Kinase B JNK: C-Jun N-terminal Kinase PTEN: Phosphatase and Tensin Homolog TGF-: Transforming Growth Factor Beta PD-1: Anti-Programmed Cell Death Protein 1 PD-L1: Programmed Death-Ligand 1 GWAS: Genome-Wide Association Studies TM6SF2: Transmembrane Protein 6 Superfamily Member 2 HSD17B13: Hydroxysteroid 17-Beta Dehydrogenase 13 MBOAT7: Membrane-Bound O-acyltransferase Domain-Containing 7 GCKR: Glucokinase Regulator PNPLA3: Patatin-like phospholipase domain-containing 3 CL: Cardiolipin CoQ: Coenzyme Q PGC1: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha References Abdallah J, Assaf S, Das A, Hirani V (2023) Effects of anti-inflammatory dietary patterns on non-alcoholic fatty liver disease: a systematic literature review

The compound works through the same NNMT inhibition mechanism in both sexes, though dosing may need adjustment based on body weight