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MOTS-c increases phosphorylated AMPK levels, which blocks the osteoclastogenesis cascade

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However, more detailed mechanistic studies have shown that protein nitration by peroxynitrite requires transition metals, such as ferrous iron

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[DOI] [PubMed] [Google Scholar] 41.Granados-Soto V., Tern-Rosales F., Rocha-Gonzlez H.I., Reyes-Garca G., Medina-Santilln R., Rodrguez-Silverio J., Flores-Murrieta F.J