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"About 17 percent of Americans will be treated for depression at some point in their lives, but there are limited treatment options and about one-third of patients do not respond to these treatments."Lscher and his colleagues generated a mouse model for depression by introducing a mutation into a gene that codes for one of the subunits of a receptor for GABA -- the second most abundant chemical used by nerve cells in the brain to communicate

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Thus, these results strongly suggest that IRAP inhibitors may facilitate memory by increasing hippocampal DSD via a GLUT 4 -mediated mechanism (Seyer et al., 2020)

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