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Researchers must dissolve the compound via a slow, gentle swirling motion, avoiding any aggressive mechanical agitation, inversion, or shaking, which can permanently disrupt the cyclic synthetic matrix

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the product information notes that refrigeration can cause a color change (darker yellow) which does not affect safety or effectiveness

This loop is the storage mechanism for B12 in normal mammals as the intrinsic factor from the stomach holds onto the B12 and saves it for the ilium to recover and send to the liver