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The interaction between alcohol and nicotine in the brains reward system, combined with the effects of alcohol and the conditioned response to smoking while drinking can contribute to the triggering of nicotine cravings when alcohol is consumed

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Notably, Cmax of protonated nicotine salts appears independent of the composition and identity of the counter anions (e.g., benzoate, lactate, levulinate) forming the salts for higher administered nicotine formulations [168]

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Upon entering the brain, nicotine binds to nicotinic acetylcholine receptors, part of the central nervous system