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The results of comparing healthy controls and patients with A pathology alone with A together with tau pathology indicate that A is associated with disturbances in iron balance, as evidenced by lower NCOA4 expression, and a decrease in GPX4 antioxidant enzyme expression in the grey matter

Importantly, homocysteine levels, which should be around 7.0, can be increased due to folic acid deficiency independent of B12 deficiency

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J Nutr 142:14101416 Lobb RJ, Jacobson GM, Cursons RT, Jameson MB (2018) The interaction of selenium with chemotherapy and radiation on normal and malignant human mononuclear blood cells

Frequent Infections and Immune Dysregulation: Glutathione is essential for the proper proliferation and function of Natural Killer (NK) cells and T-lymphocytes

3b), and upregulation of cell-cell adhesion molecule N-cadherin (CDH2) (Fig