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For that purpose, it may be necessary to examine PK/PD and toxicity profiles of all possible metabolites of ADCs with non-cleavable linkers

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Direct effects of catecholamines, thyrotropinreleasing hormone, and somatostatin on growth hormone and prolactin secretion from adenomatous and nonadenomatous human pituitary cells in culture

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( We agree with the applicant that the technology meets the cost criterion and are therefore proposing to approve the CTE with CHIRP System for new technology add-on payments for FY 2024 for the indication to provide objective kinematic data from the implanted medical device during a patient's TKA post-surgical care

Hakimi et al., 2024)