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Like cysteine, even though your body can make some glycine, it might not be enough, especially if youre older or more active and have a higher need for glycine

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Long-chain fatty acids (C14-C20) cannot cross the inner mitochondrial membrane independently

203 Furthermore, in an 18-month clinical phase 3 trial (NCT02548351), 23% of the patient cohort who received OCA achieved a reduction of NAS by at least one score without worsening fibrosis compared to 12% (37/311) in the placebo group, indicating that OCA improved inflammation and fibrosis in patients with NASH