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Firstly, it is recommended to adopt nanocrystal technology (e.g., aprepitant nanocrystals) or self-assembled prodrug nanoparticles (e.g., darutigenol prodrug nanoparticles) to improve the water solubility and intestinal absorption efficiency of GPS

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[17] The importance of lysyl oxidase-derived cross-linking was established from animal studies in which lysyl oxidase was inhibited either by nutritional copper-deficiency or by supplementation of diets with -aminopropionitrile (BAPN), an inhibitor of lysyl oxidase