The 2024 NICE guideline NG239 sets out a more intensive loading schedule for patients with neurological involvement precisely because their starting point is worse
P 35 kg m 2 , WC is more difficult technically and, thus, less accurate as a risk predictor 4,25,26
The Power of Vitamin B12 Vitamin B12 is a water-soluble vitamin thats crucial for red blood cell formation, neurological function, DNA synthesis, and energy production
It has been observed to upregulate genes associated with tissue repair and antioxidant defense while downregulating genes linked to inflammation and fibrosis
These effects are dose-dependent and typically resolve within 48 weeks as GLP-1 receptor density downregulates in the gut
Therapeutic Rationale Behind the Standard Dose The 1000 mcg dose is chosen for its quick fix of vitamin B12