Someone experiencing severe brain fog and low energy requires different support than someone primarily focused on trouble losing weight
Others have assessed B12 shots for reducing deficiency due to other causes
Always follow institutional biosafety, laboratory handling, and disposal requirements
This hypothesis is supported by several studies that have shown supplementation with SAM improves depressive symptoms (104-107)
Last reviewed: June 9, 2026 Last updated: June 9, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Weekly shots are kept up for weeks to keep Vitamin B12 levels stable