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An orally-available selective nonpeptide SST5 agonist, CRN02481, has been shown to suppress insulin secretion and increase glucose levels in both oral glucose tolerance tests and a sulfonylurea model of hyperinsulinism (61, 62)

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Additionally, pioglitazone, another insulin-sensitizing drug that exerts its glucose-lowering effects through the activation of peroxisome proliferator-activated receptors, has also been reported to ameliorate cognitive decline

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