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Data from a recent U.S

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The missense variants in GUSB , TM6SF2 , PNPLA3 and TMC4 are associated with expression levels of the corresponding gene ( cis -eQTLs) in various tissues, and the missense variant in TMC4 is also associated with liver expression of MBOAT7

The overexpression of GPX4 reduces cardiolipin peroxidation and prevents the formation of PLOOHs in the cytosol and mitochondria in response to photodynamic stress, thereby inhibiting autophagosome formation [154]

H.Thorne-LymanA.WebbP.BogardJ

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