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Macrophages and neutrophils are necessary for ER stress-induced cell loss

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doi: 10.1177/00914150241268259, 102 RamyaV.ShyamK

In some embodiments, the otic formulation comprises between about 0.0001% to about 20% by weight of the weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Studies were excluded if they did not use specifically 1 H-MRS to measure at least one of the above metabolites, if they did not report original data, and if the patient population was not specific to ALS patients

2a, average viability exceeded 85% at all tested concentrations), and can biodegrade into silicic acid end products that are readily excreted from the body 20