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As these processes are protected and modulated by estrogen, loss of estrogen following OVX reduces the level of glutamate receptors and excitatory glutamate accumulation to influence functional plasticity in prefrontal cortical neurons, which increases the risk of developing neurological insults such as stroke, dementia, Huntingtons disease, and Alzheimers disease (Wei et al., 2014

Gu ZY, Liu TQ, Liu C, Yang YN, Tang J, Song H, Wang Y, Yang Y, Yu CZ

Wang S, Wang Y, Lin L, et al

Oxidative stress causes cell membrane oxidation in the lipid peroxidation process, which alters the physical properties of cell membranes, induces changes in membrane fluidity and cell integrity

Finally, consider baseline and follow-up blood work

[DOI] [PubMed] [Google Scholar] 228.Wang R., Li J., Zhang X., Zhang X., Zhang X., Zhu Y., et al