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Our findings in brain organoids with PSEN1 mutation complement well the results in human cortical organoids challenged with A that showed an increased expression of ferroptosis-promoting factors like Phkg243, Txnrd144 and Pparg42 [50]

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ANS-DOX showed to be toxic in GSTA1-1 overexpressing cancer cells

12,13,14,15,16,17 Unfortunately, for much of the subsequent 20th century, these concepts became superseded by the neurone doctrine, such that glial responses to CNS disorders were considered to be non-specific, stereotypic, always subsequent to primary neuronal damage and of little functional consequence