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10.1016/j.theriogenology.2021.07.025 33

Cells Tissues Organs 198 , 198208 (2013)

For example, metformin, a firstline agent in PCOS for insulin resistance, has been shown in patients with type 2 diabetes to blunt NET formation: in vitro, metformin prevented chromatin decondensation and DNA release and in vivo reduced circulating NET biomarkers (e.g., dsDNA, citrullinated histone H3) independent of glucoselowering effects [93]

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Let both air-dry for at least 2030 seconds