They can induce similar states of toxicity to chemical and heavy metal poisoning, affecting the nerves, many organs, and body tissues
Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
Related to this, -KG contributes to redox homeostasis by replenishing the TCA cycle as an intermediate metabolite 19 and controls GLUT1 transcription during glucose limitation as a signaling molecule 21
Poor sleep can impair this process and increase oxidative stress
Fix: Label every vial immediately upon reconstitution
Issues such as stress, poor diet, infection, medications and toxins can slow production of glutathione and eventually deplete stores