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Multidimensional Epistasis and Fitness Landscapes in Enzyme Evolution

Schedule: Daily subcutaneous injections for 8 weeks (standard cycle)

Although most mouse models of adult-onset HD have not been analysed for changes in DA levels during pre-symptomatic stages 9 , the transgenic rat model (SPRDtgHD) expressing human m HTT with 51 CAG repeats 7 exhibits DA dynamics similar to Trkb Penk -KO mutants and is reminiscent of human HD

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The performance improvement could partially stem from modified behavioral states