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This leads to disruptions in the transcription of proteins vital to the mitochondrial ETC, thus inducing malfunction and hindering ATP synthesis, which in turn might escalate ROS generation [113]

To further assess the severity of iron deficiency, additional markers like transferrin saturation (TSAT, the percentage of the plasma protein transferrin that is bound with iron, which is decreased with deficiency) may be used

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Persons who take the androgenic hormones methandrostenolone and methyltestosterone also have an increased risk for adenomas with subsequent malignant transformation