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Arginine depletion by ADI ADI breaks down arginine intro citrulline, cells without ASS-1 expression may encounter arginine starvation upon arginine deiminase treatment

March 18, 2025

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191,193,194 Some studies report a biphasic opening (an initial transient disruption followed by a delayed, prolonged breakdown) that occurs acutely after stroke due to endothelial cytoskeleton rearrangements, which acts synergistically with activation of BBB-degrading enzymes MMP-2, MMP-3, MMP-9 and MMP-12, causing enzymatic degradation of tight junction proteins to jeopardize BBB integrity

Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown