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In MR, genetic variants are applied as instrumental variables (IVs) to access the potential causal relationship between exposure and outcome due to the random distribution of these variants during meiosis ( Materials and methods Study design An overview of the bidirectional and unidirectional two-sample MR designs is presented in Figure 2
doi: 10.1530/JOE-20-0155 128 BeharierOTyurinVAGoffJPGuerrero-SantoroJKajiwaraKChuTet al
FXR can regulate the synthesis of bile acids itself and affect glucose metabolism (inhibit hepatic gluconeogenesis, promote glycogen synthesis, and enhance insulin sensitivity)
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