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Bonaca MP, Catarig AM, Houlind K, et al

The second co-stimulatory signal arises from the engagement of B7.1 (CD80) and B7.2 (CD86) molecules on APCsincluding activated macrophages, dendritic cells, and B cellswith CD28 on T cells

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A randomized, double-blind clinical trial was conducted with two groups: a placebo group involving 30 patients and an SFN-treated group with an equal number of participants

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Unregulated use can inadvertently activate dormant cancer cells or trigger autoimmune responses [1]