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This apparent safety in rodents spanning 30+ years of research from multiple independent laboratories is genuine

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It should only be done with professional supervision and a clear understanding of goals, interactions, and side effects

Based on the estimated extinction coefficient change used to quantify flavin reduction (9000 M -1 cm -1 at 450 nm) (Crozier-Reabe and Moran, 2012), reduction of an additional 10% of the sample is observed in the second phase