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HAV and HEV are mainly transmitted via the fecaloral route, but in the developed countries, hepatitis E is predominantly a zoonosis [100]

Animal model research demonstrated that depleting GSH via inhibition of GCL triggered a cascade of lipid peroxidation and cell death in mesencephalic cultures, identifying oxidative stress from glutathione insufficiency as a likely initiating mechanism in neurodegeneration

The genetic association between the genes encoding methionine synthase and N5,10-methylenetetrahydrofolate reductase suggests a close relationship between these enzymes and the tetrahydrofolate metabolism (Figure 2) [14, 15, 16, 17]

doi: 10.1073/pnas.1813458115 20 WangXSatoRBrownMSHuaXGoldsteinJL

Dysbiosis of gut microbiota is an independent risk factor of stroke-associated pneumonia: A chinese pilot study