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10.1016/j.joen.2020.03.010 105 MontoyaG.CorreaR.ArenasJ.HozL.RomoE.ArroyoR.et al (2019)

doi: 10.3389/fphys.2019.01620

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A larger randomized, placebo-controlled intervention trial (the SELECT study) in more than 35,000 middle-aged and selenium-replete men, randomized to receive selenium (in the form of selenomethionine, 200 g/day) and/or vitamin E supplementation, was halted because of concerns regarding an increased risk of type 2 diabetes mellitus with selenium and increased risk of prostate cancer with vitamin E (84, 85)

Some people also consider it because they do not tolerate stimulant-based weight-loss products well or are not candidates for GLP-1 medications