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Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds

Semaglutide (brand names Ozempic, Wegovy, Rybelsus) and Tirzepatide (brand names Mounjaro, Zepbound) are injectable medications that help regulate blood sugar and reduce appetite by mimicking certain hormones involved in glucose regulation and digestion