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5.1 Relationship between migraine and oxidative stress 5.1.1 Clinical evidence of oxidative stress 5.1.1.1 Antioxidant capacity In contrast to the control group, patients with migraine without aura had higher total oxidative status (TOS), higher oxidative stress index (OSI), and lower total antioxidant status (TAS) (Jornayvaz and Shulman, 2010)