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The melasma and tone-unevenness reader All ages Fitzpatrick III to V most common Hyperpigmentation patterns, particularly hormonal melasma, are challenging because they recur and resist many topical approaches

With the rapid development of sequencing technologies, large-scale metagenomic datasets have revealed that site-specific microbiota perform distinct biological functions within defined microenvironments 2,3,4,5 , highlighting the heterogeneity of microbial composition across anatomical sites and underscoring the need for a multi-organ perspective

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