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Similar content being viewed by others Introduction The intracellular redox milieu is supported by the thioredoxin system, composed of the flavoenzyme thioredoxin reductase (TrxR, EC 1.8.1.9), NADPH, and its main substrate thioredoxin (Trx)

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Given that mitophagy is crucial for neuronal health and deficits in this process are genetically driven, enhancing mitophagy offers a promising therapeutic approach for treating both inherited and sporadic forms of PD